Answers are grounded in this paper and cite their sources.
We report a facile one-pot synthesis of chiral β-amino esters via direct reductive amination of β-keto esters with ammonium acetate (NH4OAc) and H2 in the presence of chiral Ru-ClMeOBIPHEP catalysts using 2,2,2-trifluoroethanol (TFE) as a solvent, leading to β-amino esters in high yields with high enantioselectivities (up to 99% ee).
No takes yet. Share an insight, caveat, or question.
Bunlaksananusorn et al. (2005) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: