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Mice which would normally succumb to a homograft reaction following lethal, total-body X irradiation and homologous marrow inoculation, may be spared if they are treated with folic acid antagonist, A-methopterin. Using different treatment schedules, varying degrees of effectiveness from increased survival following a typical reaction, to no detectable reaction, may be obtained. The relationship between drug toxicity and effectiveness in altering the homograft reaction is discussed.
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Delta E. Uphoff (1958) studied this question.
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