Why the study?
Does early anticoagulation with heparin increase hemorrhagic complications in high-risk versus low-risk patients with large cerebral embolic infarction?
Population
83 patients with hemispheric embolisms receiving anticoagulation. Excluded: loss of consciousness, seizures…
Comparison
Early anticoagulation with heparin within 72… vs High-risk group versus low-risk group
Design
Cohort
Authors
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aPTT prolongation was associated with hemorrhagic complications independent of infarct size or severity; hypothesis-generating for heparin anticoagulation in embolic stroke.
Does early anticoagulation with heparin increase hemorrhagic complications in high-risk versus low-risk patients with large cerebral embolic infarction?
Early anticoagulation in alert patients with nonseptic embolic stroke does not carry additional bleeding complications based on infarction size or clinical severity, provided aPTT is strictly monitored.
Chamorro et al. (1995) studied this question.
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