Long-term risk of venous thrombosis after stopping anticoagulants for a first unprovoked event: A multi-national cohort
Population
663 patients with a first unprovoked venous thromboembolic event (VTE), multi-national.
Design
Cohort, blinded adjudication of outcomes
Follow-up
mean 5.0 years
Authors
Discussion
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Member takes
Implication
May support risk-stratified indefinite anticoagulation after unprovoked VTE; leaves open randomized trials to confirm thresholds.
Structured PICO
P
Population
663 patients with a first unprovoked venous thromboembolic event (VTE), multi-national.
I
Intervention
Discontinuation of oral anticoagulant therapy (OAT) after short-term (3-6 months) treatment
O
Outcome
Symptomatic recurrent VTE, independently and blindly adjudicatedhard clinical
Men and high-risk women have a high long-term risk of recurrent VTE after a first unprovoked event and should be considered for indefinite anticoagulation, whereas low-risk women may safely discontinue therapy.
Cite This Study
Rodger et al. (2016) studied this question.