Double resistance to imatinib and AMG 706 caused by multiple acquired KIT exon 17 mutations in a gastrointestinal stromal tumour

effective.To our knowledge, this study is the first to describe the non-invasive visualisation of small-bowel motility in a patient group.The reduced distension did not impede the visualisation of the small-bowel wall as it was outlined by either air or gastrointestinal liquid.It had the added advantage of not affecting the bowel function by placing tubes or filling the bowel.Four distinct motility patterns could be distinguished in our patients: paralysis, shivering, uncoordinated motion and sinusoidal motion.A previous study on motility with healthy volunteers 8 observed only the sinusoi- dal pattern, suggesting a clear difference in the motility patterns between postoperative patients and healthy volunteers.It may be hypothesised that motility recovers along a defined path during postoperative convalescence starting with slight shivering, changing into irregular movements and finally developing into full sinusoidal motion.Many factors may influence postoperative bowel motility, but the effect and relevance of each are complex and remain to some extent unknown.9 10The MRI technique described here is not limited to postoperative treatment, but can be applied to a wide range of motility diseases 7 and common intestinal disorders with unknown pathomechanisms.Non-invasive MRI assessment of peristaltic motion allows rapid and reliable localisation and diagnosis of motility problems and thus could have a beneficial impact on treatment and recovery.