August 19, 1997Circulation
Is Calcium a Mediator of Infarct Size Reduction With Preconditioning in Canine Myocardium?
Population
Anesthetized dogs undergoing 1 hour of coronary occlusion and 4 hours of reperfusion
Comparison
Protocol 1: 15-minute intracoronary infusion of… vs Protocol 1: Saline infusion; Protocol 2: Saline…
Design
Preclinical
Follow-up
4 hours of reperfusion
Authors
Discussion
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Implication
Calcium signaling may mediate preconditioning in canines; hypothesis-generating for human cardioprotection targets.
Structured PICO
P
Population
Anesthetized dogs undergoing 1 hour of coronary occlusion and 4 hours of reperfusion
I
Intervention
Protocol 1: 15-minute intracoronary infusion of 20 mmol/L CaCl2 before occlusion; Protocol 2: 5-(N,N-dimethyl)-amiloride before 10 minutes of preconditioning ischemia
C
Comparator
Protocol 1: Saline infusion; Protocol 2: Saline before preconditioning, or saline/dimethylamiloride without preconditioning
O
Outcome
Infarct size (area of necrosis as a percentage of area at risk, AN/AR)surrogate
Brief intracoronary infusion of calcium mimics, and blockade of calcium influx attenuates, the infarct size reduction seen with ischemic preconditioning in a canine model.
Cite This Study
Przyklenk et al. (1997) studied this question.