Type 2 Diabetes and Atrial Fibrillation: Evaluating Causal and Pleiotropic Pathways Using Mendelian Randomization
Why the study?
Observational associations between type 2 diabetes and atrial fibrillation have been established, but causality remains undetermined.
Does genetically predicted type 2 diabetes causally increase the risk of atrial fibrillation?
Population
Individuals from genome-wide association studies (including 188 577 for LDL-C, 694 649 for BMI, and 757 601 for SBP)
Comparison
Genetically predicted type 2 diabetes vs AF risk
Design
Two-sample Mendelian randomization study
Authors
Discussion
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Member takes
Implication
T2D may increase AF risk via SBP mediation; extends MR evidence but leaves independent effects open for trials.
Structured PICO
Does genetically predicted type 2 diabetes causally increase the risk of atrial fibrillation?
P
Population
Individuals from large genome-wide association studies providing genetic association estimates for cardiometabolic exposures (188,577 for LDL-C, 694,649 for BMI, and 757,601 for systolic blood pressure) and atrial fibrillation.
I
Intervention
Genetically predicted type 2 diabetes (instrumented by 182 uncorrelated single nucleotide polymorphisms at genome-wide significance)
O
Outcome
Atrial fibrillation liability/riskhard clinical
Genetically predicted type 2 diabetes is causally associated with increased atrial fibrillation risk, but this effect appears to be mediated by systolic blood pressure.
Cite This Study
Reddy et al. (2023) studied this question.