Why the study?
Does C-type natriuretic peptide affect cardiac contractility in isolated rat heart preparations?
Population
Isolated rat papillary muscles and isolated adult rat cardiomyocytes
Comparison
C-type natriuretic peptide (CNP; 1 microM) vs Baseline (before addition of CNP)
Design
Preclinical
Follow-up
5 minutes (for time to peak tension)
Authors
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Hypothesis-generating in rodent models; leaves open translation to human ventricular function or therapy.
Does C-type natriuretic peptide affect cardiac contractility in isolated rat heart preparations?
C-type natriuretic peptide exerts a positive lusitropic and negative inotropic effect in rat cardiac muscle via a cGMP-dependent mechanism.
Brusq et al. (1999) studied this question.
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