Why the study?
Does prednisone reduce serum uric acid and improve renal function in symptomatic heart failure patients with hyperuricemia?
Does prednisone reduce serum uric acid and improve renal function in symptomatic heart failure patients with hyperuricemia?
Short-term prednisone therapy significantly reduces serum uric acid and improves renal function in symptomatic heart failure patients with hyperuricemia.
May lower uric acid and creatinine in HF hyperuricemia; leaves open confirmation in randomized trials.
OBJECTIVE: To determine the safety and efficacy of prednisone in patients with symptomatic heart failure (HF) and hyperuricemia. METHODS: Prednisone therapy was administered for a short time to 191 symptomatic HF patients with hyperuricemia (serum uric acid > 7 mg/dl). RESULTS: Prednisone significantly reduced serum uric acid by 2.99 mg/dl (p < 0.01) and serum creatinine by 0.17 mg/dl (p < 0.01). These favorable effects were associated with a remarkable increase in urine output, improvement in renal function, and improvement in clinical status. CONCLUSION: Prednisone can be used safely in symptomatic HF patients with hyperuricemia.
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Meng et al. (2015) studied this question.
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