A rationally designed mechanistic approach to anti-Markovnikov olefin hydrofunctionalization and its application to the synthesis of heterocycles are described. Porphyrin–rhodium complexes have been shown to exhibit remarkable reactivity and selectivity for each step of the proposed catalytic cycle (see scheme). A critical step of this reaction sequence is a new, facile, and remarkably general carbon–heteroatom bond-forming reductive elimination.
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Sanford et al. (2004) studied this question.
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