Palladium-Catalyzed Markovnikov Hydrocarbonylation of Aliphatic Olefins: A General Approach to Diverse Carbonyl Compounds

A unified palladium-catalyzed Markovnikov hydrocarbonylation of aliphatic olefins has been reported. The use of a biaryl scaffold monophosphine ligand is crucial to achieving excellent branched regioselectivity. This versatile catalytic system exhibits excellent compatibility with a series of nucleophiles, including anilines, water, and alcohols, enabling efficient and regioselective construction of structurally diverse branched carbonyl compounds from readily accessible aliphatic olefins. The synthetic utility of this method was demonstrated by the efficient preparation of agrochemicals and fine chemicals.