Why the study?
Does P2 purinoceptor saturation by ATP impair renal autoregulation in anesthetized dogs?
Does P2 purinoceptor saturation by ATP impair renal autoregulation in anesthetized dogs?
Saturation of P2 purinoceptors with ATP impairs renal blood flow autoregulation in dogs, supporting their role in mediating autoregulatory adjustments in renal vascular resistance.
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Supports P2 purinoceptor role in canine RBF autoregulation; leaves open human relevance and therapeutic targeting.
Majid et al. (1999) studied this question.
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