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Does tamoxifen provide renoprotective effects and reduce inflammation and fibrosis in a rat model of DOCA-salt hypertensive nephropathy?
Does tamoxifen provide renoprotective effects and reduce inflammation and fibrosis in a rat model of DOCA-salt hypertensive nephropathy?
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Tamoxifen may attenuate renal damage in hypertensive rats; leaves open translation to human hypertensive nephropathy.
Background: The present study was designed to evaluate the possible renoprotective effects of tamoxifen in deoxycorticosterone acetate (DOCA)-salt hypertensive (DSH) rats and its role in inflammation and fibrosis in the kidney. Methods: Male Sprague-Dawley rats, weighing 180 to 200 g, were used. All rats underwent unilateral nephrectomy. One week later, one group of rats (n = 8) was implanted with DOCA strips (200 mg/kg) and another group of rats (n = 8) was implanted with DOCA strips with co-treated with tamoxifen (10 mg/kg) through gavage feeding. Rats that did not implanted DOCA strips served as controls (n = 6). Two weeks later, the systolic blood pressure (SBP) was measured by tail-cuff method. The protein expression of transforming growth factor-(TGF-), Smad, -smooth muscle actin ( -SMA), E-cadherin, ED-1, cyclooxygenase-2
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Choi et al. (2013) studied this question.
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