Preclinical study demonstrates that Prevotella loescheii alleviates pregnancy-induced hypertension in animal models, suggesting a therapeutic role for gut-placental immune modulation.
Key Points
To investigate how Prevotella loescheii alters the placental microenvironment and alleviates pregnancy-induced hypertension.
Integrated single-cell RNA sequencing (scRNA-seq) with an in vivo pregnancy-induced hypertension model to characterize placental cellular and immune dynamics.
Evaluated the impact of Prevotella loescheii supplementation on placental morphology, immune cell trajectories, oxidative stress, and short-chain fatty acid metabolism.
Pregnancy-induced hypertension caused trophoblast and myeloid cell reduction, Hofbauer cell depletion, and NLRP3 inflammasome-driven macrophage pyroptosis.
Prevotella loescheii treatment restored Hofbauer cell populations, suppressed mitochondrial oxidative stress and pyroptosis, normalized short-chain fatty acid metabolism, and attenuated proteinuria and placental damage.