Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 1, 2026FASEB BioAdvancesOpen Access

MicroRNA ‐Mediated Placental Maladaptation in Preeclampsia Pathogenesis

View Full Paper
Ask AI
Bookmark
Share

Authors

SSSarbani SahaIndian Institute of Chemical BiologyRARupasri AinIndian Institute of Chemical Biology

Discussion

Loading...

Member takes

Overview

Narrative review reveals widespread microRNA dysregulation in preeclamptic placentas, highlighting critical links between gene networks and impaired trophoblast function.

Key Points

  • To summarize recent evidence on microRNA expression and function in preeclamptic placentas, specifically evaluating how aberrant microRNA signaling drives trophoblast dysfunction and disease progression.
  • Synthesized molecular and genome-wide expression literature on placental microRNA dysregulation in pregnancies affected by preeclampsia.
  • Assessed microRNA modulation of trophoblast biological behaviors, including proliferation, migration, invasion, angiogenesis, and apoptosis.
  • MicroRNA expression profiles show widespread disruption in preeclamptic placentas, primarily triggered by low oxygen microenvironments and angiogenic imbalance.
  • Dysregulated microRNAs suppress trophoblast invasion and interfere with spiral artery remodeling, impairing early placental perfusion.

Cite This Study

Saha et al. (2026) studied this question.

synapsesocial.com/papers/6aadd74cd428f1c6be648d22https://doi.org/10.1096/fba.2026-00062
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Human mesenchymal stem cells modulate allogeneic immune cell responses2004 · 4,568 citations
  2. 2Cardiovascular and Cerebrovascular Disease Associated microRNAs Are Dysregulated in Placental Tissues Affected with Gestational Hypertension, Preeclampsia and Intrauterine Growth Restriction2015 · 126 citations
  3. 3Preeclampsia Up-Regulates Angiogenesis-Associated MicroRNA ( i.e ., miR-17, -20a, and -20b) That Target Ephrin-B2 and EPHB4 in Human Placenta2012 · 179 citations
  4. 4Circulating miRNAs and Preeclampsia: From Implantation to Epigenetics2024 · 32 citations
  5. 5miR-144 may regulate the proliferation, migration and invasion of trophoblastic cells through targeting PTEN in preeclampsia2017 · 63 citations