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July 14, 2018Molecular TherapyOpen Access

MicroRNA-218-5p Promotes Endovascular Trophoblast Differentiation and Spiral Artery Remodeling

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Authors

JBJelena BrkićYork UniversityCDCaroline DunkSociety for Maternal-Fetal MedicineJOJacob A. O’BrienBrigham Young University

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Overview

Experimental study reveals that microRNA-218-5p enhances trophoblast invasion and spiral artery remodeling in human placental tissue, suggesting a protective role against preeclampsia.

Key Points

  • To investigate the role and molecular mechanism of miR-218-5p in endovascular extravillous trophoblast differentiation, spiral artery remodeling, and the pathogenesis of preeclampsia.
  • Measured miR-218-5p expression levels in human preeclampsia placentas and normal extravillous trophoblast cells.
  • Overexpressed or inhibited miR-218-5p in first-trimester trophoblast cell lines, human placental explants, and decidua-placenta co-cultures.
  • Evaluated trophoblast invasion, outgrowth, and spiral artery remodeling while manipulating transforming growth factor (TGF)-β2 signaling.
  • miR-218-5p is highly enriched in extravillous trophoblasts and significantly downregulated in preeclampsia placentas.
  • Overexpression of miR-218-5p promoted trophoblast invasion, extravillous trophoblast outgrowth, endovascular differentiation, and spiral artery remodeling, whereas miR-218-5p inhibition suppressed these processes.
  • The pro-remodeling effects of miR-218-5p were mediated by suppressing TGF-β2 signaling, with TGFB2 silencing mimicking and TGF-β2 treatment partially reversing these cellular changes.

Cite This Study

Brkić et al. (2018) studied this question.

synapsesocial.com/papers/6aae4dc5eae4d833005f3611https://doi.org/10.1016/j.ymthe.2018.07.009
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