Experimental study demonstrates light-promoted cyclization of propargylic amides with carbon dioxide to access functionalized oxazolidinediones, highlighting sustainable routes for chemical synthesis.
The conversion of CO 2 into value‐added chemicals represents a promising strategy for sustainable synthesis. Herein, we report a natural light‐promoted cyclization of propargylic amides with CO 2 using commonly used halogenating reagents as both the reaction promoter and halogen source to access 5‐(halomethylene)oxazolidine‐2,4‐diones, which enables the one‐pot construction of C─O, C─N, and C─X bonds. The protocol accommodates a broad range of substrates, and a variety of functional groups are well‐tolerated under mild reaction conditions, providing access to functionalized oxazolidine‐2,4‐diones up to 92% yield as single E isomers. The mechanistic experiments reveal that the reaction may proceed along two pathways, which are the radical pathway ( Path A ) and the halonium pathway ( Path B ). The resulting 5‐(halomethylene)oxazolidine‐2,4‐diones could be further transformed to complex molecules, highlighting the versatility.
No takes yet. Share an insight, caveat, or question.
Lu et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: