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August 20, 2026Clinical and Experimental NephrologyOpen Access

Clinical rather than genetic factors predict hepatic cyst burden and growth in autosomal dominant polycystic kidney disease: a cohort study of 332 genotyped patients

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Authors

KTKeiji TakahashiHKHaruna KawanoTKTomoki Kimura

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Overview

Retrospective cohort study reveals clinical traits and calcium channel blockers predict liver cyst growth in polycystic kidney disease, highlighting non-genetic drivers of progression.

Key Points

  • Determine whether genetic mutations, clinical characteristics, or medication exposures predict hepatic cyst burden and growth rates in patients with autosomal dominant polycystic kidney disease.
  • Retrospectively analyzed 332 genotyped patients with autosomal dominant polycystic kidney disease who underwent serial computed tomography.
  • Quantified height-adjusted total liver volume (HtTLV) and longitudinal progression using both annual percentage change and log-transformed growth metrics.
  • Evaluated associations with demographic, clinical, and medication variables using multivariable linear regression models.
  • Genotype was not associated with hepatic cyst prevalence, baseline height-adjusted total liver volume, or longitudinal growth rates.
  • Greater baseline hepatic cyst burden was independently associated with female sex, Mayo class C–E, smoking history, and higher body mass index.
  • Calcium channel blocker exposure and baseline liver volume were independently associated with accelerated hepatic cyst growth across both percentage and log-transformed models.

Cite This Study

Takahashi et al. (2026) studied this question.

synapsesocial.com/papers/6a86b5978a91293e6a1cd08chttps://doi.org/10.1007/s10157-026-02935-5
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiac complications in autosomal dominant polycystic kidney disease: links to genotype and CKD severity2025
  2. 2Effect of Pregnancy on MRI measures of Kidney and Liver Cyst Growth Rates in Autosomal Dominant Polycystic Kidney Disease (ADPKD)2025
  3. 3Clinical profile, imaging characteristics, and laboratory parameters in autosomal dominant polycystic kidney disease: a single-center observational study2026
  4. 4WCN24-2565 PREDICTORS OF RAPID PROGRESSION IN A RETROSPECTIVE AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE COHORT IN SOUTH AFRICA: PRELIMINARY RESULTS2024
  5. 5Cystic burden meets blood pressure: cardiac remodelling in paediatric autosomal dominant polycystic kidney disease2026