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August 20, 2026International Journal of Surgical Pathology

Rare Intramedullary Mature Teratoma of the Spinal Cord With Prostatic and Bulbourethral Gland Formation: A Case Report and Literature Review

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KZKaijian Zhang

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Overview

Case report demonstrates rare bulbourethral and prostatic gland formation in a spinal mature teratoma in an adult male, highlighting novel urogenital differentiation in germ cell migration.

Key Points

  • To report a unique case of an adult intramedullary mature spinal teratoma exhibiting novel bulbourethral and prostatic glandular differentiation.
  • Evaluated a 60-year-old male presenting with progressive low back and right leg pain alongside urinary incontinence using lumbar MRI.
  • Performed microsurgical gross total resection of an L1 intraspinal lesion measuring 15.0 mm × 16.6 mm × 29.4 mm, followed by histopathological and immunohistochemical examination.
  • Pathology confirmed mature teratoma containing derivatives of all three germ layers, including endodermal bulbourethral glands and prostatic acinar structures positive for PSA, P504S, 34βE12, and p63.
  • Mesodermal and ectodermal elements included smooth muscle, focal vascular spaces, cells resembling adrenal zona reticularis, glial tissue, and nerve bundles.
  • Gross total surgical resection resulted in marked postoperative symptom relief without immediate recurrence.

Cite This Study

Kaijian Zhang (2026) studied this question.

synapsesocial.com/papers/6a86b5978a91293e6a1cd15chttps://doi.org/10.1177/10668969261467352
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