What question did this study set out to answer?

To evaluate age-related alterations in lumbar spine trabecular bone microarchitecture using trabecular bone score (TBS) and establish age-specific normative reference ranges in healthy adult women.

August 20, 2026Menopause The Journal of The North American Menopause Society

Age-specific reference values for lumbar spine trabecular bone score (TBS) in Brazilian adult women

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To evaluate age-related alterations in lumbar spine trabecular bone microarchitecture using trabecular bone score (TBS) and establish age-specific normative reference ranges in healthy adult women.
Assessed lumbar spine TBS and bone mineral density (BMD) in 527 healthy women aged 20–82 years using a Hologic Discovery A DXA system and TBS iNsight software.
Restricted primary analytical models (n=477) to BMI 15–37 kg/m² while excluding hormone therapy users, stratifying by age decade and analyzing years since menopause using restricted cubic splines.
TBS declined independently with age after adjusting for height and weight (β = -0.004 per year, P < 0.001) and with years since menopause in postmenopausal women (β = -0.002 per year, P = 0.010).
Established reference cutoffs of 1.365 for normal and 1.248 for degraded microarchitecture based on premenopausal women aged 20–39 years.
Identified impaired trabecular microarchitecture in 34.8% to 41.6% of women who exhibited normal BMD across skeletal sites.

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Implication

Cross-sectional study demonstrates earlier age-related microarchitecture decline via trabecular bone score than bone density in women, indicating enhanced fracture risk assessment.

Cite This Study

Gomes et al. (2026) studied this question.

synapsesocial.com/papers/6a86b5da8a91293e6a1cd634 https://doi.org/10.1097/gme.0000000000002847

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Implication

Cross-sectional study demonstrates earlier age-related microarchitecture decline via trabecular bone score than bone density in women, indicating enhanced fracture risk assessment.

Age-specific reference values for lumbar spine trabecular bone score (TBS) in Brazilian adult women

Key Points

Discussion

Implication

Cite This Study

Age-specific reference values for lumbar spine trabecular bone score (TBS) in Brazilian adult women

Key Points

Discussion

Implication

Cite This Study

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