What question did this study set out to answer?

To establish the minimal clinically important difference thresholds for the Reflux Symptom Score, Reflux Symptom Score-12, and Reflux Symptom Index in patients with laryngopharyngeal reflux disease.

August 20, 2026Otolaryngology

Minimal Clinically Important Difference of Reflux Symptom Score, Reflux Symptom Score‐12, and Reflux Symptom Index

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Authors

JLJérôme R. LechienCentre National de la Recherche Scientifique

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Implication

Prospective study establishes meaningful symptom score reduction thresholds in laryngopharyngeal reflux disease, highlighting clear benchmarks for treatment response and medication weaning.

Key Points

To establish the minimal clinically important difference thresholds for the Reflux Symptom Score, Reflux Symptom Score-12, and Reflux Symptom Index in patients with laryngopharyngeal reflux disease.
Prospectively recruited 351 consecutive patients (208 females) diagnosed with laryngopharyngeal reflux disease via 24-hour hypopharyngeal-esophageal impedance-pH monitoring at a university hospital.
Assessed symptoms pre- and post-treatment using RSS, RSS-12, RSI, and RSA, using the RSS-Quality-of-Life score as the clinical anchor for treatment response.
Calculated minimal clinically important differences using receiver operating characteristic curve analysis and Youden's index.
RSS-Quality-of-Life strongly correlated with RSS (rho = 0.697), RSS-12 (rho = 0.783), and RSI (rho = 0.776; all P < .001), validating its anchor role across 127 responders (36.2%) and 224 nonresponders (63.8%).
ROC analysis demonstrated high discriminative performance for RSS (AUC = 0.822; 95% CI: 0.78–0.87), RSS-12 (AUC = 0.827; 95% CI: 0.78–0.87), and RSI (AUC = 0.867; 95% CI: 0.76–0.97).
Identified MCID thresholds of a 35-point decrease for RSS (sensitivity 81.1%, specificity 69.6%), 20 points for RSS-12 (sensitivity 85.3%, specificity 68.2%), and 8 points for RSI (sensitivity 77.3%, specificity 88.6%).

Cite This Study

Jérôme R. Lechien (2026) studied this question.

synapsesocial.com/papers/6a86b5ff8a91293e6a1cd9f0 https://doi.org/10.1002/ohn.70379

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Implication

Prospective study establishes meaningful symptom score reduction thresholds in laryngopharyngeal reflux disease, highlighting clear benchmarks for treatment response and medication weaning.

Minimal Clinically Important Difference of Reflux Symptom Score, Reflux Symptom Score‐12, and Reflux Symptom Index

Discussion

Member takes

Implication

Key Points

Cite This Study

Minimal Clinically Important Difference of Reflux Symptom Score, Reflux Symptom Score‐12, and Reflux Symptom Index

Discussion

Member takes

Implication

Key Points

Cite This Study

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