What question did this study set out to answer?

To investigate the photoprotective effects of HX114, a combined extract of Actinidia arguta and Perilla frutescens, on the epidermal barrier and dermal structural integrity under UVB irradiation.

August 20, 2026Journal of Medicinal Food

Combined Extracts of Actinidia arguta and Perilla frutescens , HX114, Exert Photoprotective Effects on Epidermal Barrier Function and Dermal Matrix Integrity in UVB-Irradiated Hairless Mice

View Full Paper

Ask AI

Bookmark

To investigate the photoprotective effects of HX114, a combined extract of Actinidia arguta and Perilla frutescens, on the epidermal barrier and dermal structural integrity under UVB irradiation.
SKH-1 hairless mice were fed diets supplemented with HX114 (200, 400, or 800 mg/kg body weight, or 1% in diet) for 10 weeks concurrent with UVB irradiation.
Skin hydration, transepidermal water loss (TEWL), surface pH, epidermal thickness, and wrinkle indices were measured alongside molecular biomarkers and matrix-remodeling enzymes.
HX114 supplementation dose-dependently improved skin hydration, reduced TEWL, prevented epidermal thickening, and reduced wrinkle formation in UVB-exposed mice.
Dietary HX114 restored epidermal barrier components by increasing free amino acids, ceramides, filaggrin, peptidylarginine deiminase 3, and caspase-14 while reducing aCDase expression.
HX114 preserved dermal matrix integrity by elevating type I collagen and hyaluronic acid levels via suppression of MMP1/MMP13 and upregulation of TIMP1.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Animal study demonstrates that dietary HX114 preserves epidermal barrier function and dermal matrix integrity in UVB-irradiated hairless mice, indicating strong photoprotective properties.

Cite This Study

Kim et al. (2026) studied this question.

synapsesocial.com/papers/6a86b6208a91293e6a1cdcff https://doi.org/10.1177/1096620x261479617

View Full Paper

Ask AI

Bookmark

Implication

Animal study demonstrates that dietary HX114 preserves epidermal barrier function and dermal matrix integrity in UVB-irradiated hairless mice, indicating strong photoprotective properties.

Combined Extracts of Actinidia arguta and Perilla frutescens , HX114, Exert Photoprotective Effects on Epidermal Barrier Function and Dermal Matrix Integrity in UVB-Irradiated Hairless Mice

Key Points

Discussion

Implication

Cite This Study

Combined Extracts of Actinidia arguta and Perilla frutescens , HX114, Exert Photoprotective Effects on Epidermal Barrier Function and Dermal Matrix Integrity in UVB-Irradiated Hairless Mice

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider