Key result
Dextrose infusion during moderate exercise prevented the attenuation of plasma glucagon and epinephrine responses to subsequent hypoglycemia compared to exercise without dextrose.
Why the study?
Does dextrose administration to maintain euglycemia during moderate intensity exercise prevent the attenuation of counterregulatory responses to subsequent hypoglycemia in healthy adults?
Does dextrose administration to maintain euglycemia during moderate intensity exercise prevent the attenuation of counterregulatory responses to subsequent hypoglycemia in healthy adults?
The attenuation of counterregulatory responses to hypoglycemia after exercise is likely driven by the hypoglycemia that occurs during exercise rather than the exercise itself.
Hypoglycemia during exercise, not exercise itself, likely attenuates counterregulation; hypothesis-generating for glycemic strategies in diabetes.
Hypoglycemia, which occurs commonly during and following exercise in people with diabetes, is thought to be due to attenuated counterregulation in the setting of therapeutic insulin excess. To better understand the pathophysiology of counterregulation, we aimed to determine if dextrose administration to maintain euglycemia during moderate intensity exercise alters the attenuation of counterregulatory responses to subsequent hypoglycemia in healthy adults : Counterregulatory responses to hypoglycemia were assessed in 18 healthy adults after bed rest and following exercise with (n = 9) and without (n = 9) dextrose infusion. Responses were measured during a stepped euglycemic-hypoglycemic clamp 24 h after either bed rest or two 90-min bouts of exercise at 70% peak oxygen uptake : Hypoglycemia occurred during the second bout of exercise without dextrose infusion. Plasma glucagon and epinephrine responses to stepped hypoglycemia after antecedent exercise without dextrose infusion were significantly lower at the 45 mg/dL glycemic level compared to after bed rest. However, no attenuation of the counterregulatory responses to hypoglycemia was evident after antecedent exercise when dextrose was infused. This study suggests that the attenuation of the counterregulatory responses during hypoglycemia after exercise is likely due to the hypoglycemia that occurs during moderate prolonged exercise and not solely due to exercise or its intensity.
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Cade et al. (2016) studied Healthy adults (n=18). Dextrose infusion during exercise vs. Exercise without dextrose infusion was evaluated on Plasma glucagon and epinephrine responses to stepped hypoglycemia at the 45 mg/dL glycemic level. Dextrose infusion during moderate exercise prevented the attenuation of plasma glucagon and epinephrine responses to subsequent hypoglycemia compared to exercise without dextrose.
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