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December 1, 2000Dermatologic Surgery

The History of Substances for Soft Tissue Augmentation

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Authors

AKArnold William KleinUniversity of California, Los AngelesMEMelvin L. ElsonRonald Reagan UCLA Medical Center

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Implication

Historical review reveals the evolution of injectable filler substances in dermatologic practice, highlighting significant advancements in clinical biocompatibility and safety.

Key Points

  • Review the historical progression, clinical safety profiles, and material evolution of substances employed for soft tissue augmentation.
  • Narrative historical review synthesizing the medical literature on synthetic and biologic substances used for soft tissue filling and contour restoration.
  • Outlines the chronological transition from early, poorly tolerated filler agents to advanced, biocompatible compounds.
  • Identifies key technological innovations that substantially reduced chronic foreign body reactions and improved material longevity.

Cite This Study

Klein et al. (2000) studied this question.

synapsesocial.com/papers/6a86c398d00295e3b4beef0dhttps://doi.org/10.1046/j.1524-4725.2000.00512.x
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Treatment of Depressed Scars with Fibrin Foam—Seventeen Years of Experience1975 · 27 citations
  2. 2Quantitative Assessment of Augmentation Therapy1990 · 47 citations
  3. 3Injectable Fluid Silicone Therapy1975 · 144 citations
  4. 4Bioplastique1991 · 79 citations