Key result
Frailty (n=29) was an independent prognostic factor for significantly worse overall and cancer-specific survival compared to non-frailty (n=58) after hepatectomy for colorectal liver metastasis.
Why the study?
The study was conducted to investigate frailty as a prognostic factor in patients with colorectal liver metastasis undergoing hepatectomy.
Does frailty predict prognosis in patients with colorectal liver metastasis undergoing hepatectomy?
Cohort (n=87)
No
Does frailty predict prognosis in patients with colorectal liver metastasis undergoing hepatectomy?
Frailty is an independent prognostic factor for worse overall and cancer-specific survival in patients undergoing hepatectomy for colorectal liver metastasis.
Frailty identifies higher-risk patients for colorectal liver metastasis resection; hypothesis-generating and requires prospective validation before guiding practice.
BACKGROUND/AIM: The aim of this study was to investigate frailty as a prognostic factor in patients with colorectal liver metastasis undergoing hepatectomy. PATIENTS AND METHODS: Eighty-seven patients who underwent hepatectomy at our institution were enrolled. Frailty was defined as a score of ≥4 on a clinical frailty scale. Patients were divided into frailty (n=29) and non-frailty (n=58) groups. RESULTS: Overall and cancer-specific survival rates were significantly worse in the frailty group compared with the non-frailty group, and multivariate analysis revealed frailty as an independent prognostic factor. Disease-free survival tended to be worse in the frailty group. Fifty-eight patients relapsed after the first hepatectomy. Twenty-one of 58 recurrent patients were allocated to the frailty group. After recurrence, chemotherapy was significantly more frequently performed in the non-frailty group compared with the frailty group. CONCLUSION: Frailty can predict the prognosis of patients with colorectal liver metastasis undergoing hepatectomy.
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Tokuda et al. (2021) conducted a cohort in Colorectal liver metastasis (n=87). Frailty vs. Non-frailty was evaluated on Overall and cancer-specific survival. Frailty (n=29) was an independent prognostic factor for significantly worse overall and cancer-specific survival compared to non-frailty (n=58) after hepatectomy for colorectal liver metastasis.
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