Key result
Among hospitalized patients with rheumatic diseases, gout had the strongest association with atrial fibrillation (OR 1.25), followed by vasculitis and polymyalgia rheumatica.
Why the study?
Studies have suggested that AF in patients with rheumatic diseases may be due to inflammation, but the specific association and associated morbidity and mortality among hospitalized patients remained to be determined.
What is the association of atrial fibrillation with different rheumatic diseases, and does it impact in-hospital mortality and morbidity?
Cohort (n=3,949,203)
Yes
What is the association of atrial fibrillation with different rheumatic diseases, and does it impact in-hospital mortality and morbidity?
Atrial fibrillation is highly prevalent in hospitalized patients with rheumatic diseases, particularly gout and vasculitis, and is associated with a two-fold increase in in-hospital mortality.
Answers are grounded in this paper and cite their sources.
Gout may warrant closer AF monitoring in rheumatic inpatients; hypothesis-generating and should not yet change practice.
BACKGROUND: Studies have suggested that atrial fibrillation (AF) in patients with rheumatic diseases (RD) may be due to inflammation. AIM: To determine the highest association of AF among hospitalized RD patients and to determine morbidity and mortality associated with AF in hospitalized patients with RD. METHODS: The National inpatient sample database from October 2015 to December 2017 was analyzed to identify hospitalized patients with RD with and without AF. A subgroup analysis was performed comparing outcomes of AF among different RD. RESULTS: without AF. Among the RD subgroup, the highest mortality was found with scleroderma (4.8%), followed by vasculitis (4%) and dermatopolymyositis (3.5%). CONCLUSION: A highest association of AF was found with gout followed by vasculitis, and polymyalgia rheumatica when compared to other RD. Mortality was two-fold higher in patients with RD with AF.
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Khan et al. (2021) conducted a cohort in Rheumatic diseases (n=3,949,203). Gout (as a specific rheumatic disease) vs. Other rheumatic diseases was evaluated on Odds of atrial fibrillation (OR 1.25, 95% CI 1.25-1.26, p=<0.0001). Among hospitalized patients with rheumatic diseases, gout had the strongest association with atrial fibrillation (OR 1.25), followed by vasculitis and polymyalgia rheumatica.
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