October 31, 2018European Heart Journal - Cardiovascular Imaging
Prognostic value of left atrial strain in predicting cardiovascular morbidity and mortality in the general population
Key result
Left atrial peak reservoir strain was a univariable predictor of incident IHD, HF, or cardiovascular death (HR 1.25; 95% CI 1.09-1.43; P=0.002), but remained an independent predictor only in women.
Why the study?
Does left atrial peak reservoir strain predict incident IHD, HF, or cardiovascular death in the general population?
Population
385 participants from the general population without atrial fibrillation, heart failure, and ischaemic heart…
Design
Cohort
Follow-up
median 12.6 years (interquartile-range 11.5-12.8 years)
Authors
Discussion
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Implication
Should not yet change risk assessment; leaves open sex-specific prognostic value of left atrial strain for prospective validation.
Study Design
Type
Cohort (n=385)
Structured PICO
Does left atrial peak reservoir strain predict incident IHD, HF, or cardiovascular death in the general population?
P
Population
385 participants from the general population without atrial fibrillation, heart failure, or ischaemic heart disease, followed for a median of 12.6 years.
E
Exposure
Left atrial peak reservoir strain (LA RS) measured by two-dimensional speckle tracking echocardiography
O
Outcome
Composite of incident IHD, HF, or cardiovascular deathcomposite
Main Result
Hazard Ratio: 1.25 (95% CI 1.09–1.43)
p-value: p=0.002
Left atrial reservoir strain provides independent prognostic value for cardiovascular morbidity and mortality in women, but not in men, in the general population.
Cite This Study
Modin et al. (2018) conducted a cohort in general population (n=385). Left atrial peak reservoir strain (LA RS) was evaluated on composite of incident IHD, HF, or cardiovascular death (HR 1.25, 95% CI 1.09-1.43, p=0.002). Left atrial peak reservoir strain was a univariable predictor of incident IHD, HF, or cardiovascular death (HR 1.25; 95% CI 1.09-1.43; P=0.002), but remained an independent predictor only in women.