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ALTHOUGH folic acid administration to patients with tropical sprue improves the clinical state and reverses the megaloblastic anemia its effects on the abnormality of the jejunal mucosa are less clear.1 Alterations induced by folic acid antagonists in the jejunal mucosa in man2 , 3 and in animals4 are the result of acute total folate deprivation and therefore are not strictly comparable to those induced by nutritional folate deficiency.The purpose of the present study was to ascertain whether nutritional folate deficiency of sufficient degree to cause megaloblastic changes in the hematopoietic tissues would be associated with significant changes in the jejunal mucosa. . . .
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Winawer et al. (1965) studied this question.
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