Why the study?
Does induction of sepsis protect the heart from ischemia-reperfusion injury in chronically alcoholic rats?
Population
Chronically alcoholic rats (alcohol as 36% of caloric intake for 8-10 weeks) and control rats
Comparison
Induction of sepsis via administration of… vs Nonseptic control and alcoholic rats
Design
Preclinical
Follow-up
1 day
Authors
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Sepsis may protect against ischemia-reperfusion injury despite chronic alcoholism; hypothesis-generating in animals and requires human validation.
Does induction of sepsis protect the heart from ischemia-reperfusion injury in chronically alcoholic rats?
Sepsis induces a protective effect against ischemia-reperfusion injury in the heart, even in the setting of severe cardiac compromise from chronic alcoholism.
McDonough et al. (1994) studied this question.
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