Key result
Low skeletal muscle mass was significantly associated with an increased odds of arteriosclerosis (OR 1.435) in a general adult population.
Why the study?
To explore the prevalence of and correlation between low muscle mass and arteriosclerosis across gender and age groups, increasing attention to arteriosclerosis risk factors in young and middle-aged individuals.
Is low skeletal muscle mass associated with an increased risk of arteriosclerosis in healthy adults?
Cross-Sectional (n=36,374)
No
Is low skeletal muscle mass associated with an increased risk of arteriosclerosis in healthy adults?
Low skeletal muscle mass is independently associated with an increased risk of arteriosclerosis across different age and sex groups in a large Chinese cohort.
Answers are grounded in this paper and cite their sources.
Low muscle mass was associated with arteriosclerosis in younger adults; leaves open causality and need for prospective intervention trials.
Objectives: This study explored the prevalence and the correlation between low muscle mass and arteriosclerosis in different gender and age groups, to increase the attention paid to the risk factors of arteriosclerosis in the young and middle-aged population. Methods: This was an analytical, cross-sectional study. Data were obtained from healthy individuals recruited from the Health Management Center of W Hospital. The brachial-ankle pulse-wave velocity was used as an indicator of arteriosclerosis, and a bioelectrical impedance analysis was used to assess the body composition. Results: A total of 36,374 subjects (men, 58.4%; women, 41.6%; mean age, 43.74 ± 12.34 years [range, 18–80 years]) participated in this study. The prevalence of low skeletal muscle mass and arteriosclerosis was 17.7 and 53.1%, respectively, in all subjects. Low skeletal muscle mass was significantly associated with arteriosclerosis (OR: 1.435, 95% CI: 1.343–1.533, P < 0.001) in all subjects, and the association remained significant in young age (OR: 1.506, 95% CI: 1.353–1.678, P < 0.001), middle-age (OR: 1.329, 95% CI: 1.195–1.479, P < 0.001), and old age (OR: 1.676, 95% CI: 1.191–2.358, P = 0.003), and also significant in men (OR: 1.559, 95% CI: 1.396–1.740, P < 0.001) and women (OR: 1.266, 95% CI: 1.143–1.401, P < 0.001). Conclusions and Implications: Our results show that the prevalence of low muscle mass and arteriosclerosis is high in the general population, even among middle-aged people and young people, and confirmed that there is a significant independent association between low skeletal muscle mass and arteriosclerosis in all subjects and in different age and gender subgroups.
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Li et al. (2021) conducted a cross-sectional in Arteriosclerosis (n=36,374). Low skeletal muscle mass vs. Normal skeletal muscle mass was evaluated on Arteriosclerosis (baPWV ≥1,400 cm/s) (OR 1.435, 95% CI 1.343-1.533, p=<0.001). Low skeletal muscle mass was significantly associated with an increased odds of arteriosclerosis (OR 1.435) in a general adult population.
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