Key result
High appendicular skeletal muscle mass index was associated with a lower risk of arterial stiffness in both men (OR 0.730; 95% CI 0.682-0.782) and women (OR 0.634; 95% CI 0.593-0.677).
Why the study?
Evidence suggests body composition impacts arterial stiffness, but evidence in Chinese populations is limited and controversial.
Is skeletal muscle mass associated with arterial stiffness in community-dwelling adults aged 45 years and older?
Cross-Sectional (n=20,477)
Is skeletal muscle mass associated with arterial stiffness in community-dwelling adults aged 45 years and older?
Odds Ratio: 0.73 (95% CI 0.682–0.782)
p-value: p=<0.0001
Low skeletal muscle mass is significantly associated with increased arterial stiffness in middle-aged and older Chinese adults.
High muscle mass was associated with lower arterial stiffness odds; hypothesis-generating and should not yet change practice.
BACKGROUND: Evidence suggests that body composition has impact on arterial stiffness. However, evidence in Chinese are limited, and results remain controversial. The aim of our study is to investigate whether skeletal muscle mass is associated with arterial stiffness in Chinese community-dwelling men and women aged 45 years and older. METHODS: In this cross-sectional study, 20,477 participants (age range: 45-80 years, 68.8% women) were included in the analysis. Brachial-ankle pulse wave velocity (baPWV), an indicator of arterial stiffness was measured using a waveform device. Total muscle mass and muscle mass of arm, leg and trunk were measured by bioelectrical impedance analysis. Height and weight were measured and appendicular skeletal muscle mass index (ASMI) was calculated as appendicular skeletal muscle mass (sum of arm and leg muscle mass) divided by height square. RESULTS: After adjustment for age, body fat percentage, systolic blood pressure and diastolic blood pressure, ASMI was negatively associated with baPWV [β (SE) for men: - 0.208 (0.016), p < 0.0001; for women: - 0.245 (0.012), p < 0.0001]. High ASMI was a protective factor for the presence of arterial stiffness (defined as baPWV) [OR (95%CI) for men: 0.730 (0.682, 0.782), p < 0.0001; women: 0.634 (0.593, 0.677), p < 0.0001]. Similar associations were found between quantity of muscle mass (total and appendicular muscle mass, muscle mass of arm, leg and trunk) and arterial stiffness in men and women after further adjustment for height (all p < 0.0001). CONCLUSION: Low skeletal muscle mass is associated with increased risk of arterial stiffness in Chinese community-dwelling adults aged 45 years and older.
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Yang et al. (2020) reported a cross-sectional. High appendicular skeletal muscle mass index (ASMI) vs. Low appendicular skeletal muscle mass index was evaluated on Presence of arterial stiffness (defined as baPWV) (OR 0.730, 95% CI 0.682-0.782, p=<0.0001). High appendicular skeletal muscle mass index was associated with a lower risk of arterial stiffness in both men (OR 0.730; 95% CI 0.682-0.782) and women (OR 0.634; 95% CI 0.593-0.677).
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