January 1, 1995IEEE Transactions on Biomedical Engineering

A model study of propagation of early afterdepolarizations

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Population

Two-element kinetic model of the ventricular action potential

Design

Preclinical

Authors

MWMary B. WagnerJohn Wiley & Sons (United States)WGWilliam J. GibbLawrence Berkeley National Laboratory MLMichael D. LeshElectrophysiology

Discussion

Member takes

Implication

Improving cellular coupling or Ca channel inhibition may suppress EAD-triggered activity; hypothesis-generating for arrhythmia models.

Structured PICO

Population

Two-element kinetic model of the ventricular action potential

Intervention

Approximating early afterdepolarizations (EADs) by a sinusoidal driving force and altering potassium and calcium channels

Outcome

Triggering of action potentials (effects of interelement coupling resistivity, sinusoidal frequency, and amplitude)surrogate

Computational modeling suggests that triggered activity due to early afterdepolarizations may be suppressed by improving cellular coupling or inhibiting calcium channels.

Cite This Study

Wagner et al. (1995) studied this question.

synapsesocial.com/papers/6a86c9666892d63992cf78fa https://doi.org/10.1109/10.464373

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A model study of propagation of early afterdepolarizations

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A model study of propagation of early afterdepolarizations

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider