April 1, 1982Circulation ResearchOpen Access

Electrotonic interactions across an inexcitable region as a cause of ectopic activity in acute regional myocardial ischemia. A study in intact porcine and canine hearts and computer models.

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Population

Isolated porcine and canine hearts, and computer models

Design

Preclinical

Follow-up

first minutes after coronary occlusion

Authors

MJM J Janse FCF J van CapelleAmsterdam UMC Location University of Amsterdam

Discussion

Member takes

Implication

Hypothesis-generating for ischemic ventricular ectopy; clinical relevance and therapeutic implications require human validation.

Structured PICO

Population

Isolated porcine and canine hearts, and computer models

Intervention

Coronary occlusion to induce acute regional myocardial ischemia, and computer simulations of conduction block

Outcome

Origin and mechanism of ventricular premature beats (VPB)surrogate

This study provides mechanistic evidence that ventricular premature beats in acute regional ischemia may be caused by triggered automaticity driven by injury currents across an inexcitable border zone.

Cite This Study

Janse et al. (1982) studied this question.

synapsesocial.com/papers/6a86c9666892d63992cf78fc https://doi.org/10.1161/01.res.50.4.527

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Bookmark

Electrotonic interactions across an inexcitable region as a cause of ectopic activity in acute regional myocardial ischemia. A study in intact porcine and canine hearts and computer models.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Electrotonic interactions across an inexcitable region as a cause of ectopic activity in acute regional myocardial ischemia. A study in intact porcine and canine hearts and computer models.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider