Key result
Acute cerebral infarction is linked to markedly elevated BNP and microproteinuria, correlating with larger infarcts.
Why the study?
The relationship of serum brain natriuretic peptide and microproteinuria levels with infarct volume, location, and prognosis in acute cerebral ischemia was not well established.
Does acute ischemic stroke increase serum BNP and microproteinuria levels compared to healthy controls?
Case-Control (n=90)
No
Does acute ischemic stroke increase serum BNP and microproteinuria levels compared to healthy controls?
Elevated BNP and microproteinuria levels in the acute phase of ischemic stroke may serve as biomarkers for infarct volume and adverse prognosis.
Answers are grounded in this paper and cite their sources.
Elevated BNP and microproteinuria may mark larger infarcts and worse prognosis; hypothesis-generating and requires prospective validation before clinical use.
Objective: In this study, serum brain natriuretic peptide (BNP) level and microproteinüria level in 24 hour-collected urine were measured in patients with acute cerebral ischemia. The relation between BNP and microproteinuria levels with cranial computerized tomographic (CT) infarct volume, infarct location and their relation with prognosis were investigated. Material and Methods: We studied 60 patients and 30 controls. Plasma BNP levels and microproteinuria were measured. CT was performed to calculate the infarct volume using the Cavalieri method. Results: The average BNP and proteinuria levels were 415.17±507.36 pg/ml, and 197.35±175.04pg/dl in the study group, 22.0±78 pg/ml and 23.17±12.97 mg/dl in control group respectively, and the differences were statistically significant difference (p˂0.001). There was statistically significant positive correlation between BNP and proteinuria levels (r=0.39, p<0.001). While the average BNP and proteinuria levels were 590.08±547.05 pg/ml and 265.96±224.29 pg/dl respectively in worse prognosis group; the average BNP and proteinuria levels were 272.06±429.56 pg/ml and 141.21±90.23 mg/dl respectively in the group with favorable prognosis, and the differences were statistically significant (p=0.004, p=0.005). A positive correlation was found between infarct size in cranial CT and BNP as well as proteinuria levels (r=0.36, p=0.003 and r=0.28, p=0.028, respectively). Conclusion: Our results have shown that serum BNP and microproteinuria levels were high in patients with acute cerebral infarct. The positive correlation between BNP levels and infarct volume may suggest considering whether the infarct area may be the source of BNP, and the positive correlation of bothof these parameters with wprse prognosis may be used as a prognostic indicator.
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Ulvi et al. (2013) conducted a case-control in Acute ischemic stroke (n=90). Acute ischemic stroke vs. Healthy controls was evaluated on Serum brain natriuretic peptide (BNP) level (p=<0.001). Serum brain natriuretic peptide and microproteinuria levels were significantly higher in patients with acute cerebral infarct compared to controls, and were positively correlated with infarct volume and worse prognosis.
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