What question did this study set out to answer?

To establish normative models of biological age across multiple brain and body organ systems and evaluate their utility in predicting chronic disease and mortality.

April 6, 2023Nature MedicineOpen Access

Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality

View Full Paper

Ask AI

Bookmark

Authors

YTYe TianThe University of Melbourne VCVanessa CropleyOrygen Youth Health AMAndrea B. MaierThe Royal Melbourne Hospital

Discussion

Member takes

Implication

Cohort study reveals multiorgan biological aging networks and predicts mortality risk in middle-aged adults, highlighting opportunities for targeted disease prevention.

Key Points

To establish normative models of biological age across multiple brain and body organ systems and evaluate their utility in predicting chronic disease and mortality.
Modeled biological aging profiles for three brain and seven body organ systems using longitudinal brain imaging and physiological phenotypes from the UK Biobank cohort.
Profiled organ-specific biological aging across 16 chronic diseases and tested associations with lifestyle factors, leukocyte telomere length, and survival.
Biological aging in individual organs selectively influenced aging rates in other systems, establishing an interconnected multiorgan aging network.
Advanced biological aging spread from the primary affected organ to multiple secondary organ systems across 16 chronic diseases.
Advanced body age predicted overall survival time (AUC = 0.77) and premature mortality (AUC = 0.86), while correlating with shorter leukocyte telomere lengths.

Cite This Study

Tian et al. (2023) studied this question.

synapsesocial.com/papers/6a86cc1295f8a96500d3b0f0 https://doi.org/10.1038/s41591-023-02296-6

View Full Paper

Ask AI

Bookmark

Implication

Cohort study reveals multiorgan biological aging networks and predicts mortality risk in middle-aged adults, highlighting opportunities for targeted disease prevention.

Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality

Discussion

Member takes

Implication

Key Points

Cite This Study

Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider