Extracorporeal Irradiation of the Blood and Lymph in the Treatment of Leukemia and for Immunosuppression

Diagnosis and Treatment1 August 1967Extracorporeal Irradiation of the Blood and Lymph in the Treatment of Leukemia and for ImmunosuppressionEUGENE P. CRONKITE, M.D.EUGENE P. CRONKITE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-2-415 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBefore one logically can consider perturbation of lymphopoiesis, immunity, or leukemic cell proliferation by killing cells in blood flowing through an extracorporeal radiation field, it is essential to understand the interrelations of blood and lymphatic lymphocytes or leukemic cells to their formative tissues. The notion of perturbing homeostasis in general by physical treatment (cold, radiation, etc.) of the blood flowing through an extracorporeal shunt was first published by Heymans (1) in 1921. However, it was not until a clear pattern of lymphocytic function, migration, and lifespan emerged that development of procedures to deplete the body of lymphocytes (analogous to hemorrhage...References1. HEYMANS JF: Iso-hyper et hypothermisation des mammiferes par calorification et frigorification du sang de la circulation carotido-jugulaire anastomosée. Arch. Int. Pharmacodyn. 25: 1, 1921. Google Scholar2. YOFFEYCOURTICE JMFC: Lymphatics, Lymph, and Lymphoid Tissue. Harvard University Press, Cambridge, 1956. Google Scholar3. GOWANSMCGREGOR JLBD: The immunological activities of lymphocytes. Progr. Allerg. 9: 1, 1965. Google Scholar4. CRONKITEJANSENMATHERNIELSENUSENIKADAMIKSIPE EPCRGCNOEAERCR: Studies on lymphocytes. I. Lymphopenia produced by prolonged extracorporeal irradiation of circulating blood. Blood 20: 203, 1962. CrossrefMedlineGoogle Scholar5. SLATKINJANSENCRONKITEROBERTSON DNCREPJS: Extracorporeal irradiation of the blood: calculations of the radiation dose. Radiat. Res. 19: 409, 1963. CrossrefMedlineGoogle Scholar6. MARSAGLIATHOMAS GED: The radiation dose accumulated by blood during extracorporeal irradiation. Radiat. Res. 25: 269, 1965. CrossrefMedlineGoogle Scholar7. SIPECHANANACRONKITEJOELSCHNAPPAUF CRADEPDDH: The influence of varying dose and repetitive short sessions of extracorporeal irradiation of the blood on the production of lymphopenia. Ibid., p. 684. Google Scholar8. COTTIERCRONKITEJANSENRAISINGERSIPE HEPCRKRSCR: Studies on lymphocytes. 3. Effects of extracorporeal irradiation of the circulating blood upon the lymphoreticular organs in the calf. Blood 24: 241, 1964. CrossrefMedlineGoogle Scholar9. CRONKITEJANSENCOTTIERRAISIPE EPCRHKRCR: Lymphocyte production measured by extracorporeal irradiation, cannulation, and labeling techniques. Ann. N.Y. Acad. Sci. 113: 566, 1964. CrossrefMedlineGoogle Scholar10. CHANANABRECHERCRONKITEJOELSCHNAPPAUF ADGEPDDH: The influence of extracorporeal irradiation of the blood and lymph on skin homograft rejection. Radiat. Res. 27: 330, 1966. CrossrefMedlineGoogle Scholar11. OLIVERSHEPSTONE RBJ: Extracorporeal irradiation of the blood: the mathematical problem of dosimetry. Brit. J. Haemat. 10: 181, 1964. CrossrefMedlineGoogle Scholar12. SCHIFFERATKINSCHANANACRONKITEGREENBERGJOHNSONROBERTSONSTRYCKMANS LMHLADEPMLHAJSPA: Extracorporeal irradiation of the blood in humans; effects upon erythrocyte survival. Blood 27: 831, 1966. CrossrefMedlineGoogle Scholar13. MERRILLCRONKITESCHIFFERCARPENTER JPEPLMCB: Extracorporeal irradiation as an adjunct to immunosuppression. Transplantation 4: 541, 1966. Google Scholar14. WOLFLEEO'FOGHLUDHAHUME JSHMFTDM: Effect of circulating blood radiation with an extracorporeal strontium-90 shunt on transplantation immunity in dogs and man. Surg. Forum 17: 245, 1966. MedlineGoogle Scholar15. LAJTHALEWISOLIVERGUNNINGSHARPCALLENDER LGCLRAJAAS: Extracorporeal irradiation of the blood. A possible therapeutic measure. Lancet 1: 353, 1962. CrossrefMedlineGoogle Scholar16. CRONKITECHANANASCHNAPPAUF EPADH: Extracorporeal irradiation of blood and lymph in animals: its effect on homografts and on lymphoma. New Eng. J. Med. 272: 456, 1965. CrossrefMedlineGoogle Scholar17. THOMASEPSTEINESCHBACHPRAGERBUCKNERMARSAGLIA EDRBJWECDG: Treatment of leukemia by extracorporeal irradiation. New Eng. J. Med. 273: 6, 1965. CrossrefMedlineGoogle Scholar18. SCHIFFERCHANANACRONKITEGREENBERGJOELSCHNAPPAUFSTRYCKMANS LMADEPMLDDHPA: Extracorporeal irradiation of the blood. Seminars Hemat. 3: 154, 1966. MedlineGoogle Scholar19. PERRYMOXLEYWEISSZELEN SJHGHM: Studies of leukocyte kinetics by liquid scintillation counting in normal individuals and in patients with chronic myelocytic leukemia. J. Clin. Invest. 45: 1383, 1966. CrossrefGoogle Scholar20. CRONKITE EP: Kinetics of leukemic cell proliferation, in Symposium on Perspectives in Leukemia. Blood. In press, 1967. MedlineGoogle Scholar21. SCHIFFERATKINSCHANANACRONKITEGREENBERGSTRYCKMANS LMHLADEPMLPA: Extracorporeal irradiation of blood (ECIB) in man. II. Treatment of acute myelocytic leukemia. Blood. In press. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Upton, New YorkFrom the Division of Experimental Pathology, Medical Research Center, Brookhaven National Laboratory, Upton, N. Y.This research was supported by the U. S. Atomic Energy Commission, Washington, D. C.Requests for reprints should be addressed to Eugene P. Cronkite, M.D., Head, Division of Experimental Pathology, Medical Research Center, Brookhaven National Laboratory, Upton, Long Island, N. Y. 11273. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byExtracorporeal Photopheresis in the Treatment of Mycosis Fungoides and Sézary SyndromeEugene P. Cronkite—The man and his scienceThe North American Experience with PhotopheresisChapter 8: Perspectives for the use of biological indicators for the assessment of radiation induced responses and impairments: Biologic indicators of exposure: Are markers associated with oncogenesis useful as biologic markers of effect?The role of irradiation in solid organ transplantationLymphatisches SystemChronic Myelogenous Leukemia — New ConceptsCurrent status of blastic transformation in chronic myelogenous leukemiaThe role of extracorporeal irradiation of blood in treatment of leukemiaDie Therapie der chronischen myeloischen LeukämieA 90 Sr– 90 y Applicator for Extracorporeal Blood IrradiationEffect of leukopenia and leukocytosis on tumor growth and survival time.Part I. LeukopeniaEffect of leukopenia and leukocytosis on tumor growth and survival time.Part II. LeukocytosisOfficial Organ of the Radiological Societies of Denmark, Finland, Norway and Sweden :Portable 90 Sr- 90 Y Applicator with Interchangeable Plastic Shunt for Extracorporeal Blood IrradiationImmunsuppression durch Bestrahlung 1 August 1967Volume 67, Issue 2Page: 415-423KeywordsBloodBlood cellsCell proliferationHemorrhageHomicideImmunityLymphLymphocytesLymphocytic leukemiaResearch laboratories Issue Published: 1 August 1967 PDF downloadLoading ...