What question did this study set out to answer?

To evaluate the molecular mechanisms, optimization strategies, and clinical efficacy of photodynamic therapy across precancerous skin conditions and non-melanoma skin cancers.

July 18, 2026International Journal of Molecular SciencesOpen Access

Photodynamic Therapy for Keratinocytic Precancerous Lesions and Non-Melanoma Skin Cancer: A Narrative Review

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To evaluate the molecular mechanisms, optimization strategies, and clinical efficacy of photodynamic therapy across precancerous skin conditions and non-melanoma skin cancers.
Synthesized peer-reviewed literature published from 2010 to 2025 indexed across major biomedical databases.
Assessed outcomes across actinic keratosis, field cancerization, Bowen disease, basal cell carcinoma, and cutaneous squamous cell carcinoma.
Photodynamic therapy yields high clinical clearance and excellent cosmetic outcomes for superficial lesions, with daylight-activated protocols offering a well-tolerated alternative for widespread dysplasia.
Therapeutic success decreases substantially in thick nodular, pigmented, or high-risk malignancies due to tissue hypoxia and impaired light penetration.
Physical and chemical enhancements, such as ablative fractional lasers, iron chelators, epigenetic modulators, and nanocarriers, improve drug delivery and therapeutic response in resistant lesions.

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Implication

Narrative review demonstrates high efficacy of photodynamic therapy in superficial skin neoplasias, highlighting the need for physical and chemical enhancements in aggressive lesions.

Cite This Study

Russano et al. (2026) studied this question.

synapsesocial.com/papers/6a86d2c3d25f83eb47154670 https://doi.org/10.3390/ijms27146396

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Implication

Narrative review demonstrates high efficacy of photodynamic therapy in superficial skin neoplasias, highlighting the need for physical and chemical enhancements in aggressive lesions.

Photodynamic Therapy for Keratinocytic Precancerous Lesions and Non-Melanoma Skin Cancer: A Narrative Review

Key Points

Discussion

Implication

Cite This Study

Photodynamic Therapy for Keratinocytic Precancerous Lesions and Non-Melanoma Skin Cancer: A Narrative Review

Key Points

Discussion

Implication

Cite This Study

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