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October 1, 1980CirculationOpen Access

Therapeutic implications of slow-channel blockade in cardiocirculatory disorders.

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Why the study?

Do slow-channel inhibitors provide therapeutic benefits in patients with cardiocirculatory disorders compared to beta-blockers?

Population

Patients with cardiocirculatory disorders including arrhythmias, myocardial ischemic syndromes…

Comparison

Slow-channel inhibitors vs Beta-blockers (discussed as a comparison)

Design

Review

Authors

GEGray EllrodtCCChristopher ChewBSBramah N. Singh

Discussion

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Overview

May support CCB preference in vasospastic angina; leaves open updated RCTs versus beta-blockers.

Structured PICO

Do slow-channel inhibitors provide therapeutic benefits in patients with cardiocirculatory disorders compared to beta-blockers?

P
Population
Patients with cardiocirculatory disorders including arrhythmias, myocardial ischemic syndromes, hypertension, exertional angina, and vasospastic angina
I
Intervention
Slow-channel inhibitors (verapamil, nifedipine, diltiazem)
C
Comparator
Beta-blockers (discussed as a comparison)

Slow-channel inhibitors (calcium channel blockers) are highlighted as a significant advance in cardiovascular therapeutics, particularly for their coronary vasodilatory properties in treating vasospastic and exertional angina.

Cite This Study

Ellrodt et al. (1980) studied this question.

synapsesocial.com/papers/6a86d34036c36f97809eb916https://doi.org/10.1161/01.cir.62.4.669
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Double-blind Evaluation of Verapamil, Propranolol, and Isosorbide Dinitrate against a Placebo in the Treatment of Angina Pectoris1973 · 188 citations
  2. 2Management of unstable angina at rest by verapamil. A double-blind cross-over study in coronary care unit.1979 · 204 citations
  3. 3The effect of Verapamil on the cardiac conduction system in man1974 · 80 citations
  4. 4Modification of Myocardial Infarction Size After Coronary Occlusion1973 · 311 citations
  5. 5Verapamil in ischaemic heart disease—quantitative assessment by serial multistage treadmill exercise1976 · 35 citations