Key result
Punicic acid ameliorates obesity-related hyperlipidemia and fatty liver in mice by regulating intestinal flora, elevating short-chain fatty acids, and restoring colonic barrier function.
Punicic acid shows potential as a nutraceutical for treating lipid metabolic disorders by improving intestinal barrier function and modulating gut microbiota in a mouse model.
PSO may warrant human trials for lipid disorders; leaves open clinical utility pending higher-level evidence.
, and elevated levels of microbiota-derived short-chain fatty acids (SCFAs). Moreover, the expression of tight junction proteins correlated with intestinal barrier function was notably restored in the colon. The collected results indicate that PSO may be an effective nutraceutical ingredient for attenuating lipid metabolic disorders.
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Chen et al. (2024) studied this question. Punicic acid ameliorates obesity-related hyperlipidemia and fatty liver in mice by regulating intestinal flora, elevating short-chain fatty acids, and restoring colonic barrier function.
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