Key result
Ambient ozone exposure in patients with coronary artery disease was associated with acute changes in cardiovascular biomarkers, including a 40.5% increase in plasminogen activator inhibitor-1.
Why the study?
Does ambient ozone exposure alter markers of inflammation, fibrinolysis, and endothelial cell function in patients with coronary artery disease?
Population
13 adults with stable coronary artery disease, mean age 63, 100% male, based in North Carolina, USA. Key…
Design
Cohort
Follow-up
Up to 10 weeks (two consecutive days per week)
Authors
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May inform environmental counseling in CAD; extends biomarker data but leaves causal effects and practice change open.
Observational (n=13)
No
Does ambient ozone exposure alter markers of inflammation, fibrinolysis, and endothelial cell function in patients with coronary artery disease?
Effect estimate: 40.5% increase (95% CI 8.7, 81.6)
p-value: p=0.01
Ambient ozone exposure is associated with acute adverse changes in inflammation, fibrinolysis, and endothelial function in patients with coronary artery disease, even at concentrations below EPA standards.
Mirowsky et al. (2017) conducted an observational in Coronary artery disease (n=13). Ambient ozone exposure vs. Unexposed/reference group (per interquartile range increase) was evaluated on Change in plasminogen activator inhibitor-1 (PAI-1) per interquartile increase in ozone (5-day moving average) (40.5% increase, 95% CI 8.7, 81.6, p=0.01). Ambient ozone exposure in patients with coronary artery disease was associated with acute changes in cardiovascular biomarkers, including a 40.5% increase in plasminogen activator inhibitor-1.
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