Key result
The presence of motor signs in early-stage Alzheimer disease was associated with an increased risk for cognitive decline (RR 1.72; 95% CI 1.24-2.38), functional decline, institutionalization, and death.
Why the study?
Does the presence of motor signs predict cognitive decline, functional decline, institutionalization, and death in patients with early-stage Alzheimer disease?
Population
533 patients with Alzheimer disease at early stages
Comparison
Presence of motor signs vs Absence of motor signs
Design
Cohort
Follow-up
up to 13.1 years (mean 3 years)
Authors
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Motor signs may flag higher-risk early AD patients; hypothesis-generating for prognostic models and trials.
Cohort (n=533)
Yes
Does the presence of motor signs predict cognitive decline, functional decline, institutionalization, and death in patients with early-stage Alzheimer disease?
Relative Risk: 1.72 (95% CI 1.24–2.38)
The presence of motor signs in early-stage Alzheimer disease is a significant predictor of faster cognitive and functional decline, as well as increased risk of institutionalization and mortality.
Paulin et al. (2005) conducted a cohort in Alzheimer disease (n=533). Presence of motor signs vs. Absence of motor signs was evaluated on Cognitive decline (Columbia Mini-Mental State Examination 20/57 [MMSE 10/30]) (RR 1.72, 95% CI 1.24 to 2.38). The presence of motor signs in early-stage Alzheimer disease was associated with an increased risk for cognitive decline (RR 1.72; 95% CI 1.24-2.38), functional decline, institutionalization, and death.