Key result
RNA-seq revealed 493 differentially expressed lncRNAs, with TCONS_00161198 promoting fat deposition and TCONS_00185937 potentially facilitating fat degradation in pig subcutaneous fat precursor cells.
Why the study?
This study was conducted to identify lncRNAs associated with fat deposition in Kele pigs and investigate their molecular regulatory mechanisms.
Population
Six healthy 10-month-old male Kele pigs
Comparison
High backfat thickness (>5%, H) vs low backfat thickness (<5%, L) group
Design
Preclinical whole-transcriptome RNA-sequencing and in vitro functional study
Authors
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Identifies candidate lncRNAs for porcine fat deposition; leaves open any role in human cardiometabolic disease.
p-value: p=<0.05
TCONS_00161198 and TCONS_00185937 regulate target genes to affect fat deposition in pig subcutaneous fat precursor cells, providing a theoretical basis for regulating fat deposition in Kele pigs.
Zhang et al. (2025) studied Fat deposition (n=6). High backfat thickness vs. Low backfat thickness was evaluated on Differentially expressed lncRNAs (p=<0.05). RNA-seq revealed 493 differentially expressed lncRNAs, with TCONS_00161198 promoting fat deposition and TCONS_00185937 potentially facilitating fat degradation in pig subcutaneous fat precursor cells.