Why the study?
Does severe depression affect plasma 11-O.H.C.S. level reduction following a midnight dexamethasone suppression test?
Population
27 patients with severe depression
Design
Cohort
Authors
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DST non-suppression may mark severe depression severity; leaves open biomarker role without prospective validation.
Does severe depression affect plasma 11-O.H.C.S. level reduction following a midnight dexamethasone suppression test?
Severe depressive illness is associated with resistance to dexamethasone suppression of plasma 11-O.H.C.S., which resolves upon clinical recovery.
Carroll et al. (1968) studied this question.
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