Key result
The rs1748195 polymorphism at the ANGPTL3 gene loci was associated with an elevated risk for the existence of a coronary occlusion of >50%.
Why the study?
The ANGPTL3 gene has been reported to be associated with cardiovascular risk, but its rs1748195 variant had not been evaluated alongside coronary artery occlusion >50% in an Iranian population.
Is the rs1748195 ANGPTL3 gene polymorphism associated with an increased risk of coronary artery occlusion >50%?
Case-Control (n=501)
Is the rs1748195 ANGPTL3 gene polymorphism associated with an increased risk of coronary artery occlusion >50%?
The rs1748195 polymorphism of the ANGPTL3 gene is associated with an elevated risk of significant angiographic coronary occlusion in an Iranian population.
No immediate change to CAD risk assessment; leaves open validation of ANGPTL3 genotyping for clinical use.
SUBJECT: The Angiopoietin-like 3 (ANGPTL3) gene has been reported to be associated with cardiovascular risk. This study is designed to compare the genetic variant (rs1748195) of the ANGPTL3 gene and the presence of a coronary artery occlusion of >50% in Iranian nation. METHOD: In this study, 184 patients underwent angiography and 317 healthy individuals were evaluated for polymorphism of rs1748195 the ANGPTL3 gene using Tetra-ARMs PCR. Coronary patients who experience angiography were categorized into two groups: 54 patients who had an angiography indication for the first time and coronary occlusion was <50% (Angio-) and 134 patients who formerly underwent coronary stent implanting at least 1 month before with coronary occlusion of ≥50% that again have an angiography indication (Angio+). In addition, individuals with angio+ are categorized in two groups: (1) non-in-stent restenosis (NISR); patient with a patent stent (N = 92). (2) in-stent restenosis (ISR); in-stent stenosis >50% (N = 42). RESULT: The fundamental of characteristics of our study design population was categorized based on undergoing angiography or not. In the present study, we investigated that the CC genotype, and also the A allele corresponding to rs1748195 at the ANGPTL3 gene loci, was associated with negative angiogram and directly related to the risk of coronary occlusion >50%. In contrast, this result was not significant in genotypes of ANGPTL3 between non-ISR and ISR groups. CONCLUSION: The outcomes of this study showed that rs1748195 polymorphism at the ANGPTL3 gene loci is associated with an elevated risk for the existence of a coronary occlusion of >50%.
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Afkhami et al. (2022) conducted a case-control in Coronary artery disease (n=501). rs1748195 ANGPTL3 gene polymorphism vs. Healthy individuals or absence of the risk allele was evaluated on Presence of a coronary artery occlusion of >50%. The rs1748195 polymorphism at the ANGPTL3 gene loci was associated with an elevated risk for the existence of a coronary occlusion of >50%.
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