Effects of Splenectomy on Red-cell Production in Myelofibrosis

of Haematological Findings (Fig. 2).-Thispatient maintained a haemoglobin level of between 8.3 and 12 g./100ml. for five years after the diagnosis of myelo- fibrosis.The haemoglobin level then fell to 5 g./ 100 ml. and could hardly be raised by transfusion.Isotope studies showed greatly reduced red-cell production and there was evidence of shortened red-cell life.Prednisone therapy had