The Circulating Lymphocyte—Its Role in Infectious Mononucleosis

This Combined Clinical Staff Conference presents some of the newer findings in basic biology of the lymphocyte and illustrates how investigational techniques of tissue culture, virology, immunology, and fine structural analysis have been useful in studying some salient clinical features in infectious mononucleosis. Recent clinical studies and findings are summarized. The proliferative potential of the circulating lymphocyte and the isolation and characterization of continuous lymphoid cell lines derived from peripheral blood of patients with infectious mononucleosis are discussed. The microbial isolation pattern from patients and specific host immunologic responses are presented in light of recently identified virus-like particles in cell lines derived from patients with infectious mononucleosis.