Key result
Cryo-electron microscopy revealed the 4.78-Å resolution structure of the full-length, closed myosin Va heavy chains in complex with calmodulin, uncovering an asymmetric autoinhibition mechanism.
Why the study?
The molecular mechanisms governing the autoinhibition and activation of myosin Va remain unclear.
The study reveals the structural basis for the autoinhibition and activation of myosin Va, demonstrating how cargo binding regulates its motor activity.
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Offers structural basis for myosin Va regulation; leaves open cardiovascular relevance pending functional validation.
Niu et al. (2022) studied this question. Cryo-electron microscopy and biochemical analysis was evaluated. Cryo-electron microscopy revealed the 4.78-Å resolution structure of the full-length, closed myosin Va heavy chains in complex with calmodulin, uncovering an asymmetric autoinhibition mechanism.
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