Key result
A 2.3-Å resolution structure of apo-myosin-Ib revealed a unique orientation of structural elements and a cavity holding an N-terminal region that tunes the rate of the force-sensitive transition.
The N-terminal region of myosin-Ib plays a critical role in tuning its mechanochemical properties and stabilizing the post power-stroke conformation.
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Elucidates myosin-Ib force sensitivity; leaves open relevance to human cardiac myosins or disease models.
Shuman et al. (2014) studied this question. A 2.3-Å resolution structure of apo-myosin-Ib revealed a unique orientation of structural elements and a cavity holding an N-terminal region that tunes the rate of the force-sensitive transition.
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