Key result
During isometric contraction, actin orientation changes occurred in bursts of activity lasting 1.2 ± 0.4 s separated by 2.3 ± 1.0 s, suggesting 36% of cross-bridges are involved in force generation.
Population
Skeletal muscle actin and myosin molecules
Comparison
Isometric contraction induced by ATP vs Low concentration of ATP
Design
Preclinical
Authors
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Supports burst-like cross-bridge recruitment during isometric contraction in animal models; hypothesis-generating for human cardiac mechanics and therapeutic targeting.
Myosin cross-bridges interact with actin in bursts during isometric contraction, with approximately 36% of cross-bridges involved in force generation during active periods.
Mettikolla et al. (2010) studied this question. Isometric contraction was evaluated on Time course of orientation change of actin molecules. During isometric contraction, actin orientation changes occurred in bursts of activity lasting 1.2 ± 0.4 s separated by 2.3 ± 1.0 s, suggesting 36% of cross-bridges are involved in force generation.
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