Key result
Two novel ankyrin-B isoforms, AnkB-188 and AnkB-212, were identified in mammalian hearts and shown to have distinct subcellular distributions and functions regulating specific protein interactions.
Population
Human ventricular tissue, rat, and mouse hearts; cardiomyocytes
Design
Preclinical
Authors
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Extends ANK2 splicing biology in mammalian hearts; leaves open relevance to human arrhythmias or therapies.
Alternative splicing of the ANK2 gene produces two functionally distinct ankyrin-B isoforms that regulate specific protein interactions and excitation-contraction coupling in the heart.
Wu et al. (2015) studied this question. AnkB-188 and AnkB-212 overexpression or knockdown was evaluated on Function and subcellular distribution of ankyrin-B isoforms. Two novel ankyrin-B isoforms, AnkB-188 and AnkB-212, were identified in mammalian hearts and shown to have distinct subcellular distributions and functions regulating specific protein interactions.
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